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Finally, Ins-SeNPs exhibit excellent hypoglycemic effects after oral administration, requiring a lower oral dose to achieve a long-acting glycemic reduction than insulin alone for the same time and concentration (0.75 μg·mL −1 ) [446]

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Additionally, amino acid depletion by ʟ-asparaginase that induces serum amino acid depletion by L-Asn and L-Gln hydrolysis sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death (187)